{"id":674,"date":"2022-01-25T04:41:00","date_gmt":"2022-01-25T04:41:00","guid":{"rendered":""},"modified":"2023-09-05T23:05:44","modified_gmt":"2023-09-05T15:05:44","slug":"circlednas-whole-exome-sequencing-technology-explained","status":"publish","type":"post","link":"https:\/\/magazine.circledna.com\/circlednas-whole-exome-sequencing-technology-explained\/","title":{"rendered":"Which DNA Testing is Most Accurate? CircleDNA\u2019s Whole Exome Sequencing Technology Guarantees Accuracy"},"content":{"rendered":"

Most, if not all, people should have asked this question when they first start choosing between myriad DNA tests: which DNA testing is most accurate?<\/em> While we cannot tell you which test is the best or the most accurate, we can show you how our team has endeavored to maintain a high accuracy with a cutting-edge technology, and still striving to do better.<\/p>\n

Health conditions<\/a>, behavioral issues and medical problems<\/a> are often caused by our genetics. Whole Exome Sequencing is a type of genetic sequencing often used by scientists to understand what may be causing a disease, or a person\u2019s mysterious symptoms, from a genetic perspective.<\/p>\n

DNA sequencing, the process of determining the specific order of nucleotides (DNA building blocks) in a person\u2019s genetic code, is a technology rapidly accelerating the study of genetics.<\/p>\n

Currently, many of the world\u2019s largest medical groups, including the UK\u2019s NHS<\/a>, genome centers from reputed institutions such as Harvard and Stanford Universities, leverage DNA sequencing as a tool for diagnosing and understanding genetic health disorders.<\/p>\n

Two methods of genetic sequencing, Whole Genome and Whole Exome Sequencing, are emerging as essential systems for identifying medical issues influenced by a person\u2019s DNA.<\/p>\n

Both of these methods rely on the use of state-of-the-art technologies which allow for the rapid sequencing of large amounts of DNA information.<\/p>\n

CircleDNA<\/a> tests utilize the most advanced Whole Exome Sequencing (WES) technology on the market to provide a 99.99% analytical accuracy. Are we the answer to \u201cwhich DNA testing is most accurate?\u201d? Not exactly, but our testing methods have achieved international accreditation, confirming our compliance with the highest laboratory quality testing standards.<\/p>\n

Here\u2019s what you need to know about our proven approach to DNA sequencing.<\/p>\n

What is Whole Exome Sequencing (WES)?<\/strong><\/h2>\n

Imagine each gene in your body is an individual book, making up the comprehensive library of your DNA. You need to read the whole book to understand the story behind the gene and how it relates to your health and your full potential as a human being.<\/p>\n

Whole Exome Sequencing, or WES, is a next-generation sequencing method<\/a> (NGS) approved by leading medical facilities, to provide a deeper insight into the whole story of the DNA sequence. The insights available from WES are far more comprehensive than the overview scientists used to get using traditional genotyping technology.<\/p>\n

Using the book analogy, whole-genome sequencing would allow scientists to look at every word on every page of the book in-depth, which would provide a lot of information, but not all of this data would be relevant or useful to us as human beings. Whole Exome Sequencing takes a more focused approach, by sequencing the protein-coding regions of the genome.<\/p>\n

The human exome only accounts for less than 2% of the larger genome, but it contains over 85-90%<\/a> (Botstein D et al Nat Genet. 2003) of the known disease-related variants linked to our genetics. This means with Whole Exome Sequencing; it\u2019s possible to concentrate on the most influential insights available from your DNA.<\/p>\n

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What are the Benefits of Whole Exome Sequencing?<\/strong><\/h2>\n

According to Simon Stevens, the Chief Executive of NHS England, Whole Exome Sequencing is a quick and accurate testing method that allows for more rapid diagnosis of genetic health conditions, and better insights into a person\u2019s genetic makeup. According to Stevens<\/a>, this advanced DNA sequencing technology can \u201cmore rapidly diagnose rare diseases, helping to put an end to uncertainty and allowing children to receive the best possible treatment.\u201d<\/p>\n

Because the exome represents only the most important part of the genome DNA, it can be more rapidly sequenced and interpreted, leading to faster results, and quicker treatments. Exome sequencing also has applications in a range of research applications, allowing for the evaluation of genetic disease at scale, and population genetics.<\/p>\n

When examining the entire genome isn\u2019t necessary (or cost-effective), Whole Exome Sequencing offers a cost-effective and efficient approach. Sequencing specific coding regions within the genome means researchers can focus crucial resources on the genes most likely to influence phenotype.<\/p>\n

Exome sequencing examines variants in human genetic code, with the ability to expand and dive deeper into targeted information, to include untranslated regions for better views of gene function. The CircleDNA Whole Exome Sequencing provides a full scan of your entire protein-coding regions, and custom selection of non-exonic regions that are related to many lifestyle and health-oriented conditions, with comprehensive and accurate results from more than 31 million data points<\/a>.<\/p>\n

The most significant benefits of Whole Exome Sequencing include:<\/strong><\/p>\n